572 S Salina Street offers a prime investment or owner-user opportunity in the heart of
Downtown Syracuse. This 20,943 SF, two-story professional and medical office building sits
prominently at the intersection of South Salina Street and West Adams Street—one of the most
visible corners in the central business district.
The building is configured for multi-tenant use and features a blend of general office suites and
medical-ready space. The second floor formerly housed a VA Clinic and includes medical
infrastructure with exam rooms, private offices, cubicle areas, and conference rooms. The first
floor accommodates a range of professional users such as legal, financial, or consulting firms,
with open and private layout options. Both floors offer flexible buildout capabilities to meet
modern professional, clinical, or administrative requirements.
Property features include a dramatic two-story glass atrium, continuous window lines providing
abundant natural light, an outdoor courtyard with patio seating, and approximately 3,000 SF of
additional basement storage. With 50+ dedicated surface parking spaces—rare for
downtown—this asset provides both convenience and functionality for tenants and visitors.
Located directly across from the Centro Regional Transportation Center and minutes from
Interstates 81 and 690, the property offers superior accessibility. Syracuse University, St.Joseph’s Hospital, and Crouse Hospital are all within roughly one mile, enhancing its appeal for
both professional and healthcare users.
Whether repositioned as a headquarters, multi-tenant professional hub, or specialized medical
facility, 572 S Salina Street represents a strategic opportunity in a fast-evolving downtown
corridor.
Property Facts:
● Building Size: 20,943 SF
● Floors: 2
● Typical Floor: 9,897 SF
● Land Area: 0.88 AC
● Parking: ±42–50+ surface spaces
● Construction: Steel
● Sprinklers: Wet system
● Year Built: 1990
● Zoning: MX-4 Urban Core
Highlights:
● High-visibility corner location in Downtown Syracuse
● Two-story office/medical building with flexible multi-tenant layouts
● Former VA Clinic buildout in place on second floor
● Dramatic two-story glass atrium and continuous window lines
● Outdoor courtyard with patio seating and ±3,000 SF basement storage
● Rare surface parking for downtown, with easy access to I-81 & I-690
● Close to Syracuse University and major hospitals